원료 생약 추출물의 최적화를 위한 한국 5개 지역에서 채집된 대계 추출물들의 항우울 효과 비교

• 영문명: Comparison of the Antidepressant Activity of Cirsii herbal Extracts Collected from 5 Different Regions of Korea Determining the Optimal Herbal Preparation
• 발행기관: 대한약학회
• 저자명: 이혜림(Hye Lim Lee) 준브라이언(June Bryan I. dela Pena) 윤서영(Seo Young Yoon) 김성목(Seong Mok Kim) 홍은영(Eunyoung Hong) 이용수(Yong Soo Lee) 장미란(Miran Jang) 김건희(Gun-Hee Kim) 정재훈(Jae Hoon Cheong)
• 간행물 정보: 『약학회지』제56권 제6호 (2012년), 401~406쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.12.31

영문 초록

Previously, we identified that Cirsium japonicum (CJ) extract posses antidepressant properties. In order to look for the optimal hebal preparation, CJ extracts collected from Koheung, Yesan, Cheju, Pyungchang and Pocheon were compared. The psychopharmacological activities of each extract were investigated using the open field test, the rota-rod test and the forced swimming test. Effect of each extract on Cl- influx in neuroblastoma cells were also identified. All of the extracts were orally administered at dosages of 50, 100, 200, 400 mg/kg of body weight. Supplementation of CJ did not significantly alter psychomotor behaviors such as movement, rearing frequency and total turn angle on the open field. Supplementation of CJ’s extract from Pyungchang (100 mg/kg, p.o.), Cheju (200 and 400 mg/kg p.o.) and Yesan (100 and 200 mg/kg, p.o.) significantly decreased immobile duration and increased mobile duration in the forced swimming test. All of extracts have no influence on NE uptake in HEK-293 cells, but increased Cl- influx in neuroblastoma cell. The extract from Yesan demonstrated the most potent effect on Cl- influx. These results indicate that CJ’s extracts from Pyungchang, Cheju and Yesan may alleviate depression, and the extract from Yesan may be the most effective preparation.

키워드

Cirsium japonicum psychopharmacological activity habitat depression forced swimming test