Pyridazinyl Sulfides의 산화반응; 과산화수소를 이용한 새로운 Pyridazinyl Sulfoxides 및 Pyridazinyl Sulfones의 합성

• 영문명: Oxidation of Pyridazinyl Sulfides; Synthesis of New Pyridazinyl Sulfoxides and Pyridazinyl Sulfones with Aqueous Hydrogen Peroxide
• 발행기관: 대한약학회
• 저자명: 박은희(Eun-Hee Park) 박명숙(Myung-Sook Park)
• 간행물 정보: 『약학회지』제56권 제6호 (2012년), 390~394쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.12.31

영문 초록

A series of new pyridazinyl sulfoxides 3a~e and pyridazinyl sulfones 4a were synthesized for development of candidates to retain anticancer activity. The utility of sulfoxides and sulfones in both laboratory and industrial practice was quickly recognized, and these species have been extensively utilized, including as pharmaceutical intermediates and anticancer agents. Alkylthiopyridazines 2a~e were prepared from the 3,6-dichloropyridazine using allylthiolation with alkyl mercaptan. Sulfides could be oxidized to sulfoxides or sulfones using 1~3 equivalents of hydrogen peroxide as an oxidant. The oxidation of sulfoxides to sulfones was also accomplished with aqueous hydrogen peroxide. Formation of 3a~e and 4a was undertaken with stirring using 35% hydrogen peroxide at room temperature in acetic acid for 18~72 h. Synthetic compounds were identified using NMR spectrum.

키워드

pyridazinyl sulfides pyridazinyl sulfoxides pyridazinyl sulfones oxidation hydrogen peroxide