5-Lipoxygenase에 의한 성숙 파골세포의 조절

• 영문명: The Regulatory Role of 5-Lipoxygenase in Mature Osteoclasts
• 발행기관: 대한약학회
• 저자명: 노아롱새미(A Long Sae Mi Noh) 문미란(Miran Moon) 정지은(Ji-Eun Jeong) 임미정(Mijung Yim)
• 간행물 정보: 『약학회지』제56권 제6호 (2012년), 347~351쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.12.31

영문 초록

5-Lipoxygenase (5-LO) catalyzes the formation of two major groups of leukotrienes, LTB4 and cysteinyl leukotrienes (CysLT), and it has been implicated as a promising drug target to treat various inflammatory diseases. Since its role in mature osteoclasts (mOCs) had not been reported, we investigated the effect of 5-LO inhibitors on mOCs. We showed that 5-LO inhibitors dose-dependently decreases the number of mOCs. The effects of 5-LO inhibitors were reversible, suggesting that they did not cause any cellular damages in mOCs. We further demonstrated that the suppression of mOCs by 5-LO inhibitors was caused mainly by disruption of the actin ring formation. Similar effects were shown with CysLT receptor (CysLTR)1 antagonist in mOCs. The mRNA expression of CysLTR1 and the production of CysLT were increased in mOCs. These results indicate that CysLTR1 mediates the suppression of mOCs by 5-LO inhibitors. Taken together, this study demonstrated that 5-LO plays important role in mOCs and possibly a novel therapeutic target for bone resorption diseases.

키워드

5-LO CysLTR1 mOCs bone loss