밀리타린 유도체의 합성 및 생리활성 평가

• 영문명: Synthesis and Biological Evaluation of Militarin Derivatives
• 발행기관: 대한약학회
• 저자명: 차해연(Haiyan Che) 윤덕효(Deok Hyo Yoon) 김태웅(Tae Woong Kim) 성기호(Gi-Ho Sung) 박해일(Haeil Park)
• 간행물 정보: 『약학회지』제56권 제6호 (2012년), 372~376쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.12.31

영문 초록

Militarin was isolated from Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom and reported to possess anticancer activities against several tumor cells. A number of militarin derivatives bearing different numbers of ethylene glycol unit were synthesized and evaluated for their biological activities related with anticancer and antiinflammatory effects. Among militarin derivatives tested, the compounds 2 and 5 exhibited anticancer and antiinflammatory activities.

키워드

militarin derivatives anticancer activity antiinflammatory activity NO iNOS COX-2