Berberine이 백서의 6-Hydroxydopamine-유도 파킨슨병 모델에서의 L-DOPA 요법에 미치는 영향

• 영문명: Effects of Berberine on L-DOPA Therapy in 6-Hydroxydopamine-induced Rat Models of Parkinsonism
• 발행기관: 대한약학회
• 저자명: 신건성(Kun Seong Shin) 권익현(Ik Hyun Kwon) 최현숙(Hyun Sook Choi) 임성실(Sung Cil Lim) 황방연(Bang Yeon Hwang) 이명구(Myung Koo Lee)
• 간행물 정보: 『약학회지』제55권 제6호 (2011년), 510~515쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.12.31

영문 초록

Isoquinoline compounds including berberine enhance L-DOPA-induced cytotoxicity in PC12 cells. In this study, the effects of berberine on L-DOPA therapy in unilateral 6-hydroxydopamine (6-OHDA)-induced rat models of parkinsonism were investigated. Rats were prepared for the models of Parkinson's disease by 6-OHDA-lesioning for 14 days and then treated with L-DOPA (10 mg/kg) with or without berberine (5 and 30 mg/kg, i.p.) for 21 days. Treatment with berberine (5 and 30 mg/kg, i.p.) showed a dopaminergic cell loss in substantia nigra of 6-OHDA-lesioned rats treated with L-DOPA: 30 mg/kg berberine was more intensive neurotoxic. The levels of dopamine were also decreased by berberine (5 and 30 mg/kg) in striatum-substantia nigra of 6-OHDA-lesioned rats treated with L-DOPA. These results suggest that berberine aggravates cell death of dopaminergic neurons in L-DOPA-treated 6-OHDA-lesioned rat models of Parkinson's disease. Therefore, the long-term L-DOPA therapeutic patients with isoquinoline compounds including berberine may need to be checked for the adverse symptoms.

키워드

berberine dopamine tyrosine hydroxylase 6-hydroxydopamine-lesioned rats Parkinson's disease