쿠마린 유도체의 아세틸콜린 에스테라제 저해활성 연구

• 영문명: Study on the Acetylcholinesterase Inhibitory Activity of Coumarin Derivatives
• 발행기관: 대한약학회
• 저자명: 남승옥(Seung Ok Nam) 윤용돈(Yong Don Yun) 박동현(Dong Hyun Park) 류종훈(Jong Hoon Ryu) 이용섭(Yong Sup Lee)
• 간행물 정보: 『약학회지』제55권 제6호 (2011년), 473~477쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.12.31

영문 초록

Alzheimer's disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.

키워드

acetylcholinesterase Alzheimer's disease inhibitor coumarin scopoletin memory