증숙 과정을 통한 소청룡탕의 뇌신경세포 보호 활성 변화에 관한 연구

• 영문명: Neuroprotective Activity of So Cheong Ryong Tang with Steaming Process
• 발행기관: 대한약학회
• 저자명: 원진배(Jin Bae Weon) 양혜진(Hye Jin Yang) 이보형(Bohyoung Lee) 윤보라(Bo-Ra Yun) 마진열(Jin Yeul Ma) 마충제(Choong Je Ma)
• 간행물 정보: 『약학회지』제55권 제6호 (2011년), 451~455쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.12.31

영문 초록

So Cheong Ryong Tang (SCRT) has been used as a traditional herbal medicine for the treatment of the bronchial asthma. In this study, the effect of steaming process on changes in 11 major compounds (homogentisic acid, ephedrine HCl, paeoniflorin, cinnamic acid, cinnam aldehyde, glycyrrhizin, 6-gingerol, schizandrin, methyleugenol, gomisin A and gomisin N) content and neuroprotective activity of SCRT were evaluated. Major compound content was slightly different with steaming produce. The contents of paeoniflorin, cinnamic acid, cinnam aldehyde, 6-gingerol and methyleugenol were decreased and homogentisic acid, ephedrine HCl, glycyrrhizin, schizandrin and gomisin A were increased by steaming process. The neuroprotective activity of steaming SCRT was determined in mouse hippocampal HT22 cells by MTT assay. As a result, neuroprotective activity of a steaming SCRT was higher than that of a non steaming SCRT. This study demonstrated that neuroprotective activity of SCRT can be improved through steaming process.

키워드

So Cheong Ryong Tang Steaming process Major compounds Neuroprotection