헤테로 고리를 갖는 크리신 유도체의 합성 및 항염증 작용에 대한 평가

• 영문명: Synthesis of Chrysin Analogs with a Heteroaryl Group and Evaluation for their Anti-inflammatory Activities
• 발행기관: 대한약학회
• 저자명: 차해연(Haiyan Che) 트루옹넉투엔(Ngoc Tuyen Truong) 김현표(Hyun Pyo Kim) 박해일(Haeil Park)
• 간행물 정보: 『약학회지』제55권 제6호 (2011년), 462~465쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.12.31

영문 초록

Chrysin analogs with 2-heteroaryl groups were synthesized and evaluated for their inhibitory activities against PGE2 and NO production from LPS-induced RAW 264.7 cells. Chrysin analogs were synthesized from 2-hydroxy-4,6- dimethoxy-acetophenone and heteroaryl aldehydes in 3 steps. The tested chrysin analogs showed decreased inhibitory activity against PGE2 and NO production than those of chrysin.

키워드

chrysin 2-heteroaryl anti-inflammatory PGE₂ nitric oxide