베르니케 뇌병증과 연관된 티아민(비타민 B1) 부족 시신경병증 1예

• 영문명: A Case of Thiamine (Vitamin B1)-Deficient Optic Neuropathy Associated with Wernicke’s Encephalopathy
• 발행기관: 대한안과학회
• 저자명: 김정열 허동원 이행진 이연희,Jung Yeul Kim, MD, Dong Won Heo, MD, Haeng Jin Lee, MD, Yeon Hee Lee, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number12, 1954~1959쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.12.13

영문 초록

Purpose: To report a case of subacute optic neuropathy caused by thiamine (vitamin B1) deficiency.
Case summary: A 44-year-old woman was referred to the ophthalmology department due to decreased vision which began 10 days prior to presentation. The patient history indicated that she had undergone chemotherapy for ovarian cancer and she had been dependent on total parenteral nutrition for 3 weeks due to nausea and vomiting. Her best corrected vision of the right and the left eyes were 0.15 and 0.2, respectively. Color vision was severely impaired in both eyes without retrobulbar pain. There was marginal blurring on the temporal side of the optic discs of both eyes. The optic nerves were unremarkable on orbital and brain magnetic resonance imaging (MRI). There was high signal intensities in both the mammillary body and periaqueductal gray matter on T2-weighted imaging. In addition, the patient exhibited ataxia along with short-term memory loss. She was diagnosed with Wernicke’s encephalopathy. Thiamine was administrated based on the diagnosis, and after 2 days of administration, the patient’s vision and neurologic symptoms began to improve. Two weeks later, the patient recovered her vision.
Conclusions: Thiamine deficiency may cause optic neuropathy and can be recovered with early thiamine supplementation. This condition could occur due to deficient oral thiamine administration. We should keep this point in mind and try to prevent or diagnose early.
J Korean Ophthalmol Soc 2013;54(12):1954-1959

키워드

Nutritional optic neuropathy, Thiamine, Vitamin B1, Wernicke’s encephalopathy