Pectolinarigenin ameliorated airway inflammation and airway remodeling to exhibit antitussive effect

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Quan He Weihua Liu Xiaomei Ma Hongxiu Li Weiqi Feng Xuzhi Lu Ying Li Zi Chen
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제28권 제3호, 229~237쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2024.05.01

국문 초록

Cough is a common symptom of several respiratory diseases. However, frequent coughing from acute to chronic often causes great pain to patients. It may turn into cough variant asthma, which seriously affects people's quality of life. For cough treatment, it is dominated by over-the-counter antitussive drugs, such as as-meton, but most currently available antitussive drugs have serious side effects. Thus, there is a great need for the development of new drugs with potent cough suppres-sant. BALB/c mice were used to construct mice model with cough to investigate the pharmacological effects of pectolinarigenin (PEC). Hematoxylin-eosin and Masson staining were used to assess lung injury and airway remodeling, and ELISA was used to assess the level of inflammatory factor release. In addition, inflammatory cell counts were measured to assess airway inflammation. Airway hyperresponsiveness assay was used to assess respiratory resistance in mice. Finally, we used Western blot-ting to explore the potential mechanisms of PEC. We found that PEC could alleviate lung tissue injury and reduce the release of inflammatory factors, inhibit of cough frequency and airway wall collagen deposition in mice model with cough. Mean-while, PEC inhibited the Ras/ERK/c-Fos pathway to exhibit antitussive effect. There-fore, PEC may be a potential drug for cough suppression.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

키워드

Airway Cough Inflammation