수포성 각막병증의 공초점주사현미경 소견

• 영문명: In Vivo Confocal Microscopic Findings of Corneal Tissue in Bullous Keratopathy
• 발행기관: 대한안과학회
• 저자명: 박영민 권한조 이종수,Young Min Park, MD, Han Jo Kwon, MD, Jong Soo Lee, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number12, 1923~1928쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.12.13

영문 초록

Purpose: To analyze the morphology and density of corneal tissue in patients with bullous keratopathy using in vivo confocal microscopy (IVCM).
Case summary: Four eyes of 4 patients with clinically diagnosed bullous keratopathy were examined using IVCM. Cross-sectioned corneal images of the corneal epithelium, Bowman’s layer, stromal layer, Descemet’s membrane, and endothelium were evaluated. In bullous keratopathy patients, the outline of corneal epithelial wing cells was blurred. Several hyper-reflective whitish dots were found at the corneal epithelial level and a reduction in the density and thickness of the corneal nerves was observed. There was also a reduction in the density of the stromal keratocytes. The outline of the stromal keratocytes was blurred. Some keratocytes resembled myofibroblast. The hypo-reflective vertical strands were observed in the stroma adjacent to the Descemet’s membrane. Endothelium showed hyper-reflectivity with associated increased endothelial pleomorphism and polymegathism.
Conclusions: In patients with bullous keratopathy, IVCM showed tissue edema in the corneal epithelium, stroma, and endothelium. Hyper-reflectivity appearances were noted due to the increase in the metabolic rate of the cells or extracellular matrix accumulation. Corneal endothelium showed morphological changes.
J Korean Ophthalmol Soc 2013;54(12):1923-1928

키워드

Bullous keratopathy, Confocal microscopy