쥐의 호르너 증후군 모델에서 외안근의 변화

• 영문명: The Changes in Extraocular Muscles in Horner’s Syndrome of Rats
• 발행기관: 대한안과학회
• 저자명: 송지혜 유웅선 정인영 서성욱,Ji Hye Song, MD, Woong Sun You, MD, In Young Chung, MD, Seong Wook Seo, MD, PhD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number10, 1576~1581쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.10.15

영문 초록

Purpose: The aim of this study was to understand the pathogenesis of the enophthalmos of Horner’s syndrome. Methods: We performed right cervical sympathectomy in 10 Sprague-Dawley rats weighing 200~300 grams at 8 weeks of age. We obtained bilateral extraocular muscle and fat from all 10 rats. These tissues were observed under light and electron microscopy. Results: After 8 weeks, ptosis and enophthalmos were seen in the right eye in all rats. We found no change bilateral fat, but the right extraocular muscle fibers had smaller diameters than the left. The right intermuscular distance was longer than the left upon light microscopy and the right extraocular muscle contained fewer and smaller mitochondria than the left extraocular muscle upon electron microscopy. Conclusions: Based on these results, it is believed that enophthalmos resulted from extraocular muscle atrophy that resulted from decreasing metabolism of mitochondria in Horner’s syndrome. However, enophthalmos in Horner’s syndrome requires more intensive study.

키워드

Cervical sympathectomy, Enophthalmos, Horner’s syndrome