고도근시에서 굴절교정레이저각막절제술 후 각막혼탁을 줄이기 위해 사용한 마이토마이신의 효과

• 영문명: Effect of Mitomycin C to Inhibit Corneal Haze Formation after Photorefractive Keratectomy for High Myopia
• 발행기관: 대한안과학회
• 저자명: 정병진 김현호 박영정 이광자 이규원,Byung Jin Jeong, M.D., Hyun Ho Kim, M.D., Young Jeung Park, M.D., Gwang Ja Lee, M.D., Kyoo Won Lee, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number5, 725~734쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.05.31

영문 초록

Purpose: To evaluate the safety and results of the prophylactic use of 0.02% mitomycin C (MMC) to inhibit haze formation after excimer laser photorefractive keratectomy (PRK) for high myopia in eyes that were not good candidates for laser in situ keratomileusis (LASIK) because of inadequate corneal thickness. Methods: On thirty eyes with high myopia (-6.0 to -10.13 diopters), PRK with intraoperative topical 0.02% MMC application was performed. Visual acuity, refraction, keratometry, corneal haze, central corneal thickness, corneal endothelium, repair of corneal epithelium, and other complications were evaluated for 1 year. Results: No eyes showed any BCVA loss, and some even presented a BCVA increase, except in one case: one eye had lost a line 1 year after PRK. At 1 year after surgery, the spherical equivalent was within ±0.5 D of the desired refraction in 73.33% of the cases, and 86.67% were within ±1.0 D of the intended refraction. At 3 months after surgery, the mean corneal haze scale stabilized at about 0.22, and decreased further thereafter. Central corneal thickness increased steadily postoperatively, whereas endothelial density decreased significantly, however, the percentage of hexagonal cells and coefficient of variation in cell area showed no change. Epithelial regeneration was complete within 4 days, and there were no other complications. Conclusions: The prophylactic use of a 0.02% MMC applied intraoperatively after PRK produced lower haze rates and a better visual outcome. But, due to the decrease in endothelial cell density, the safety of MMC can be determined only after long-term observation.

키워드

Corneal haze, High myopia, Mitomycin C, Photorefractive keratectomy