K+ Channel 개방제인 BRL 34915의 신장작용에 대한 신장 신경제거와 선택성 ATP-의존성 K+ Channel 차단제인 Glibenclamide의 영향

• 영문명: Effect of Renal Denervation and Glibenclamide, a selective ATP-sensitive K+ Channel Blocker, on Renal Action of BRL 34915, a ATP-sensitive K+ Channel Opener, in Dog
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 최홍석(Hong Seok Choi)
• 간행물 정보: 『약학회지』제44권 제4호 (2000년), 362~370쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.08.30

영문 초록

In anesthetized dogs, antidiuretic action of intravenously administered BRL 34915 (10.0~30.0mcg/kg) was blocked by renal denervation, whereas it was not affected by glibenclamide, a selective KATP blocker, given into renal artery. Diuretic action in ipsilateral kidney produced by intrarenal administration of BRL 34915 was not influenced by renal denervation, but blocked completely by glibenclamide given into the vein. Above results suggest that the antidiuretic action of BRL 34915 is mediated by renal sympathetic nerves and the diuretic action is caused by opening of K+ channel within kidney.

키워드

BRL 34915 diuretic and antidiuretic action denervation glibendamide dog.