1-(2-furyl)-3-phenylpropenone 유도체의 DNA Topoisomerase I 저해활성에 대한 parameter focusing

• 영문명: Parameter Focusing on the Topoisomerase I-inhibition Activities of 1-(2-furyl)-3-phenylpropenone Derivatives
• 발행기관: 대한약학회
• 저자명: 명평근(Pyung Keun Myung) 최수라(Su La Choi) 성낙도(Nack Do Sung)
• 간행물 정보: 『약학회지』제44권 제4호 (2000년), 358~361쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.08.30

영문 초록

Parameter focusing on the DNA topoisomerase-I inhibition with X-substituted phenyl substituents in 1-(2-furyl)-3-phenylpropenone derivatives as inhibition material were analyzed. From the basis on the results, the inhibition on DNA topoisomerase I suggested that the inhibition activities of X-substituted phenyl substitutents would depend largely on the net charge of beta-carbon atom, LUMO energy (e.v.) and STERIMOL parameter, B5 (width) of X. Among them, non-substituent (X=H), 1 and 2,2-dichloro substituent, 4 showed the highest DNA topoisomerase-I inhibition activity.

키워드

1-(2-furyl)-3-phenylpropenones DNA Topoisomerase-I Inhibition & para-meter focusing.