항생제 내성 및 감수성 Salmonella typhimurium 균주에 대한 개똥쑥 지상부 정유와 Kanamycin의 병용효과

• 영문명: In vitro Effects of Essential Oils from Aerial Parts of Artemisia annus L. Against Antibiotic-Susceptible and -Resistance Strains of Salmenella typhimurium
• 발행기관: 대한약학회
• 저자명: 신승원(Seung Won Shin)
• 간행물 정보: 『약학회지』제51권 제5호 (2007년), 355~360쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.10.31

영문 초록

The essential oil fraction from the aerial parts of A. annua was analyzed by GC-MS. As the results, caryophyllene oxide (11.7%), caryophyllene (7.54%), camphor (7.32%), 1,8-cineol (4.98%), and borneol (3.99%) were confirmed as the main components of the oil fraction. The effects of this oil and its main components on antibiotic-susceptible and -resistant strains of Salmonella enteritidis and S. typhimurium were assessed. A. annua oil fraction significantly inhibited all strains of the two Salmonella species examined, with minimum inhibiting concentrations (MICs) ranging from 2.0mg/ml to 8.0mg/ml. Among the main components of the oil, borneol and camphor showed relatively strong inhibiting activity with MICs between1.0 mg/ml and 4.0mg/ml. The MICs of caryophyllene and caryophyllene oxide were higher than 16 mg/ml. The combination effects of the oils with kanamycin were evaluated using a checkerboard microtiter assay. Against S. typhimurium KCCM11862 and CCARM8009 strains, the oil fraction of A. annua, camphor, and 1,8-cineol exhibited significant synergistic with kanamycin with fractional inhibitory concentration (FIC) indices in the range of 0.085 to 0.375. In conclusion, a combination of kanamycin and A. annua oil or its main component, camphor, and cineol, may be useful for reducing the minimum effective dose of antibiotic required for the treatment of resistant S. typhimurium infections.

키워드

essential oil Artemisia annua Salmenella typhimurium antibiotic-resistance kanamycin combination camphor 1,8-cineol