LPS로 유도된 급성 간독성에 대한 구기자 추출물의 보호 효과

• 영문명: The Preventive Effects of Lycii fructus Extract Against LPS-induced Acute Hepatotoxicity
• 발행기관: 대한약학회
• 저자명: 강금석(Kum Suk Kang) 권륜희(Ryun Hee Kwon) 김인덕(In Deok Kim) 이동근(Dong Geun Lee) 이재화(Jae Hwa Lee) 이상현(Sang Hyeon Lee) 하종명(Jong Myung Ha) 하배진(Bae Jin Ha)
• 간행물 정보: 『약학회지』제51권 제5호 (2007년), 296~300쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.10.31

영문 초록

The purpose of this study was to investigate the preventive effects of Lycii fructus Extract (LFE) against the acute hepatotoxicity-inducing lipopolysaccharide (LPS) in the liver. LFE of 100mg/kg concentration was intraperitoneally administered into rats at dose of 1.5ml/kg for 20days. On the day 21, 1.5ml/kg of LPS dissolved in saline was injected 4 hours before anesthetization. We examined the levels of glutamate oxaloacetate transaminase(GOT), glutamate pyruvate transaminase(GPT), lactate dehydrogenase(LDH) in serum of rats, superoxide dismutase(SOD) in mitochondrial fraction, and malondialdehyde(MDA), catalase(CAT), glutathione peroxidase(GPx) in liver homogenate. LPS-treatment markedly increased the levels of GOT, GPT, LDH and MDA, and significantly decreased those of SOD, CAT and GPx. But LFE-pretreatment decreased the levels of GOT, GPT, LDH and MDA, by 17.7%, 27.5%, 40.7% and 56.9%, respectively and increased those of SOD, CAT and GPx, by 90.5%, 78.9% and 83.8%, respectively. These results showed that the LFE had the preventive effects against the acute hepatotoxicity-inducing LPS in the liver.

키워드

Lycii fructus LPS SOD hepatotoxicity