오령산의 피오글리타존 부작용 경감 효과

• 영문명: Oryung-san Ameliorates Pioglitazone Side Effects
• 발행기관: 대한약학회
• 저자명: 신은정(Eun Jung Shin) 최한별(Han Byul Choi) 한은정(Eun Jung Han) 정성현(Sung Hyun Chung)
• 간행물 정보: 『약학회지』제51권 제5호 (2007년), 307~312쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.10.31

영문 초록

Thiazolidinediones(TZDs) induce insulin sensitization through the activation of PPARγ. However, the undesirable effect such as weight gain was observed. The purpose of this study was to find out an herbal drug that could reduce the side effects of pioglitazone. Among herbal formula that we have searched, oryung-san (OR) inhibited the differentiation of preadipocytes and did not affect on glucose uptake in 3T3-L1 adipocytes. In vitro, pioglitazone (PIO,30mg/kg), oryung-san(OR,300mg/kg), or pioglitazone co-administered with oryung-san (PIO+OR) were administered orally for 7 weeks in high fat diet (HFD) fed ICR mice and measured the body weight and blood glucose level every week. PIO+OR group significantly reduced body weight gain, triglyceride, and total cholesterol compared to PIO group. In addition, PIO+OR group showed a significant reduction of plasma glucose level (72%) compared to HFD control group. Insulin levels in PIO+OR group was also markedly decreased by 85% and 41% compared to HFD control and PIO group, respectively. Diameter of white adipocytes was decreased in the PIO+OR group compared to that in PIO group. Moreover, PIO+OR group reduced expression of PPARŗ and SREBP1a compared to PIO group. Taken together, oryung-san can improve side effects of pioglitazone, such as weight gain and edema, and shows a synergistic effect in plasma insulin levels.

키워드

pioglitazone oryung-san high fat diet PPAR-y SREBPla