개의 신장기능에 미치는 Ketanserin의 영향

• 영문명: Effect of Ketanserin on Renal Function in Dogs
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 심기정(Gee Jung Shim) 정경희(Kuong Hee Chung)
• 간행물 정보: 『약학회지』제43권 제5호 (1999년), 665~673쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.10.28

영문 초록

This study was performed in order to investigate the effect of ketanserin, a spcific antagonist of 5-HT2 receptor, on renal function in dogs. Ketanserin (50.0 and 15.0mcg/kg), when given intravenously, produced antidiuretic action accompained with the decreased amounts of sodium and potassium excreted in urine (ENa, EK) and the increased reabsorption rates of sodium and potassium in renal tubules (RNa, RK). Ketanserin (15.0 and 50.0mcg/kg) injected into the carotid artery exhibited also antiduretic action and this antidiuretic action was not affected by renal denervation. Above results suggest that ketanserin elicits antidiuretic action through central function, this central antidiuretic action is not mediated by renal nerves.

키워드

Ketanserin 5-HT2 antagonist central antidiuretic action dog.