오수유가 N-nitro-L-arginine methyl ester로 유발한 고혈압흰쥐의 심혈관계에 미치는 영향

• 영문명: Studies on the Effects of Evodiae Fructus on the Cardiovascular System in N-nitro-L-arginine Methyl Ester-induced Hypertensive Wistar Rats
• 발행기관: 대한약학회
• 저자명: 정수연(Soo Youn Chung) 이숙영(Sook Young Yi) 유태무(Tae Moo Yoo) 안미령(Mee Ryung Ahn) 최현진(Hyun Jin Choi) 정면우(Myeon Woo Chung) 류항묵(Hang Mook Rheu) 양지선(Ji Sun Yang)
• 간행물 정보: 『약학회지』제43권 제3호 (1999년), 397~403쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.06.28

영문 초록

The present study examined the effect of a methanol extract of Evodiae Fructus on the cardiovascular function in N-nitro-L-arginine methyl ester (NAME)-induced hypertensive Wistar rats after treatment over 6 weeks. In rats treated with NAME, blood pressure, weight of heart, aorta media thickness and media/lumen ratio significantly (p<0.05) increased, whereas coronary flow and heart rate of isolated heart significantly (p<0.05) decreased compared with control group at 6 weeks. In rats treated with NAME and Evodiae Fructus, blood pressure, aorta media thickness and media/lumen ratio signiflcantly(p<0.05) decreased compared with NAME treated group at 6 weeks. These results suggest that Evodiae Fructus is applicable to the treatment of hypertension and vascular hypertrophy.

키워드

NAME Evodiae Fructus Hypertension Hypertrophy.