천연물로부터 5 alpha-Reductase 활성억제 및 면포용해효과의 검색

• 영문명: Screening of 5alpha-Reductase Inhibition and Comedolytic Effects from Natural Products
• 발행기관: 대한약학회
• 저자명: 최승만(Seung Man Choi) 김창덕(Chang Deok Kim) 이민호(Min Ho Lee) 최영호(Young Ho Choi) 랑문정(Moon Jeong Rang) 안호정(Ho Jung Ahn) 윤여표(Yeo Pyo Yun)
• 간행물 정보: 『약학회지』제43권 제3호 (1999년), 342~350쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.06.28

영문 초록

The antibacterial activity against Propionibacterium acnes (P. acnes), 5alpha-reductase inhibition and comedolytic effects are the important pharmacological target sites of antiacne drugs. We previously reported on the antibacterial activities against P. acnes by natural products. In the present study the screening of 5alpha-reductase inhibition and comedolytic effects from natural products were performed. Seven natural products such as Angelica koreana Sophora flavescens, Prunus persica, Bombyx mori, Areca catechu, Galla rhois and Gleditschia koraiensis perfectly inhibited the activity of 5alpha-reductase at the concentration of 0.01% (w/v). Sixteen natural products which were shown to have the potent antibacterial activities against P.acnes or 5alpha-reductase inhibition activities were assayed for the comedolytic test. In the results of comedolytic effects on experimentally-induced comedones (EIC), Sophora flavescens showed the strongest comedolytic effect on EIC, and Polygonum cuspidatum and Angelica koreana showed stronger comedolytic effects on EIC than azelaic acid used for a positive control at the concentration of 3% (w/v). These results suggest that several natural products including Sophora flavescens can be developed as noble antiacne agents.

키워드

5α-reductase comedolytic effect antiacne agent Sophora flavescens natural product.