크라이신 7-O-크로토네이트의 물성 및 육모효과

• 영문명: Properties and Hair-growth Effect of Chrysin 7-O-crotonate
• 발행기관: 대한약학회
• 저자명: 신준수(Joon Su Shin) 김연희(Yeon Hee Kim) 정재훈(Jae Hoon Cheoung) 김양배(Yang Bae Kim) 김박광(Bak Kwang Kim)
• 간행물 정보: 『약학회지』제43권 제3호 (1999년), 316~319쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.06.28

영문 초록

Chrysin 7-0-crotonate was synthesized by condensing crotonic acid with chrysin in organic solvent, tetrahydrofuran (THF) using dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP). Its structure was identified by NMR, MS, UV, IR etc. We also investigated the physico-chemical properties and set up the quantitative analytical method of this compound. The correlation coefficient of calibration curve measured at the isobestic point (340nm) on this compound was approximately 0.9994 by absorption spectrophotometry. Detection limit was 1.6ng at S/N=3 by using a RP column by HPLC. The hair growth effect of chrysin 7-0-crotonate on the hair of black mouse (C57BL/6), was carried out using paste method. When its ethanol solution was administered to this black mouse by route of skin, this compound promoted the growth of hair.

키워드

chrysin 7-O-crotonate synthesis properties quantitative analysis pK hair-growth effect.