3-(치환) 피로리딘세파로스포린의 합성과 항균활성평가

• 영문명: Synthesis and Antimicrobial Evaluation of 3-(Substituted) Pyrrolidine Cephalosporins
• 발행기관: 대한약학회
• 저자명: 유지석(Ji Seak Yoo) 하재천(Jai Chun Ha) 고옥현(Ok Hyun Ko) 유진철(Jin Cheol Yoo) 강형룡(Hyung Ryong Kang)
• 간행물 정보: 『약학회지』제43권 제3호 (1999년), 306~315쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.06.28

영문 초록

To develop new cephalosporin antibiotics with improved antibacterial activities, a series of 7beta-[2-(2-aminothiazol-4-yl)-(Z)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-[5-(heterocycle)thiomethylpyrrolidin-3-ylthio]methyl-3-cephem-4-carboxylic acid (14-18) having aminothiazol carboxymethylethoxyimino group on the C-7 position and (heterocycle) thiomethyl pyrrolidinthiomethyl group on the C-3 position of the cephem ring were synthesized. These compounds were tested for antimicrobial activity in vitro against Gram(+) and Gram(-) bacteria. Compounds 15 and 16 showed remarkable antibacterial activity against Salmonella typhimurium TV119 and Alcalienes faecalis KCTC1004, but most of compounds showed lower activity than cefotaxime.

키워드

ACLE pyrrolidine aminothiazole-alkoxyiminocephalosporin antibacterial activiy.