사염화탄소에 의해 유발된 간독성에 대한 상백피 추출물의 간보호효과

• 영문명: Protective Effects Of Extracts of Mori Cortex Radicis on Carbon Tetrachloride-induced Hepatotoxicity
• 발행기관: 대한약학회
• 저자명: 김선여(Sun Yeou Kim) 이희삼(Heui Sam Lee) 류강선(Kang Sun Ryu) 이은주(Eun Ju Lee) 김영중(Young Choong Kim)
• 간행물 정보: 『약학회지』제43권 제3호 (1999년), 391~396쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.06.28

영문 초록

In order to evaluate the protective effects of extracts of Mori cortex radicis on carbon tetrachloride induced hepatotoxicity, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactic dehydrogenase, malondialdehyde values and glutathione S-transferase activity were measured in ICR mice. The activities of serum aminotransferase and the hepatic content of lipid peroxide after carbon tetrachloride-treatment were markedly increased than normal control but those levels were significantly decreased by the treatment of butanol fraction of Mori cortex radicis mathanol extract. Glutathione S-transferase activity was decreased by carbon tetrachloride than control, but that also inhibited by the treatment of butanol fraction of Mori cortex radicis methanol extract. These results demonstrate a possible hepatoprotective role of extracts of Mori cortex radicis against CCl4-induced hepatoxicity in vivo.

키워드

GOT(glutamic oxaloacetic transaminase) GPT((glutamic pyruvic transaminase) MDA(malondialdehyde) Lipid peroxidaton Mori cortex radicis.