크실로피닌의 합성

• 영문명: Synthesis of Xylopinine
• 발행기관: 대한약학회
• 저자명: 황순호(Soon Ho Hwang) 김남재(Nam Jae Kim) 홍유화(You Hwa Hong) 김인종(In Jong Kim) 김신규(Sin Kyu Kim)
• 간행물 정보: 『약학회지』제40권 제2호 (1996년), 131~134쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.04.30

영문 초록

3,4-Dimethoxyphenethyl amine(1) and 3,4-dimethoxybenzaldehyde were converted to compounds(4) through sucessive condensation and reduction reaction. Compound(4) was treated with methylthioacetyl chloride to give compound(5) then m-chloroperbenzoic acid(m-CPBA) treatment of compound(5) produced S-oxide(6). To obtain isoquinoline derivative(7),(8), compound(6) were treated with p-TsOH. Xylopinine(9) and it''s derivatives(10) were produced by Bischler-Napieralski reaction.

키워드

Bischler-Napieralski reaction Quinoline Xylopinine Protoberberine Methylthioacetyl chloride.