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• 영문명: Determination of Verapamil with ISE based on Ion Exchanger
• 발행기관: 대한약학회
• 저자명: 이은엽(Eun Yup Lee) 김동오(Dong O Kim) 장승현(Seung Hyun Chang) 허문회(Moon Hye Hur) 안문규(Moon Kyu Ahn)
• 간행물 정보: 『약학회지』제40권 제2호 (1996년), 135~140쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.04.30

영문 초록

Ion-selective poly(vinyl chloride)(PVC) membrane electrodes for the determination of the calcium antagonist verapamil and its pharmaceutical preparations were described. Verapamil-superchrome garnet Y(SGY), lumogallion(LG), acid red 97(AR97), Dragendorff(DD) and Meyer reagent ion pairs were inverstigated as an electroactive compound for membrane electrode. Stable potentiometric response was obtained with azo dye at pH 6.5-4.0 and with DD, and Meyer reagent at pH 6.5-3.0. The best plasticizer was 49w/w% 2-nitrophenyl octyl ether for azo dye, and 65.3w/w% tri(n-butyl) citrate for DD and Meyer reagent. Potentiometric response slopes of optimized membrane electrodes based on SGY, LG, AR97, DD, and Meyer complex for verapamil were 52.49, 54.88, 50.81, 54.13 and 49.31 mV/dec., respectively. Lower limits of linear range were 1.0X106M for SGY, LG, and AR97, while those for DD and Meyer reagent were 4X10-6M. Detection limits for all these electrodes were 1X10-5M, 4X10-6M, 1.8X10-6M, 8X10-7M, and 1X10-6M with relative standard deviation of 2.56, 3.6, 3.96, 2.56, 3.20%, respectively.

키워드

PVC membrane verapamil lumogallion superchrome gamet Y acid red 97 Dragendorff reagent Meyer reagent.