당부분에서 4''-플루오린 또는 4''-아자이드로 치환된 3''-히드록시다우노루비신과 3''-히드록시독소루비신 유도체의 합성과 항암활성

• 영문명: Synthesis and Antitumor Activity of 3''-hydroxydaunorubicin and 3''-hydroxydoxorubicin Derivatives Substituted with 4''-fluorine or 4''-azide in Sugar Moiety
• 발행기관: 대한약학회
• 저자명: 옥광대(Kwang Dae Ok) 박정배(Jeong Bae Park) 김문성(Moon Sung Kim) 정동윤(Dong Yoon Jung) 양중익(Junn Ick Yang)
• 간행물 정보: 『약학회지』제40권 제2호 (1996년), 117~125쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.04.30

영문 초록

3''-Deamino-3''-hydroxy-4''-fluoro- or 3''-deamino-3''-hydroxy-4''-azido-daunorubicin(6,8) and -doxorubicin(7,9) have been synthesized, respectively. Compounds 7,8 and 9 were more cytotoxic than daunorubicin(1) and doxorubicin(2) against L1210 murine leukemic cell in vitro. When administered intraperitoneally for 9 days starting 1 day after tumor inoculation, compounds 7(T/C 605%) and 9(T/C 488%) showed significant antitumor activity for ip-inoculuated L1210 murine leukemia at wide range of doses.

키워드

Anthracycline Antitumor activity WHT assay.