Phenazine dioxide 유도체가 간 Xanthine Oxidase 활성에 미치는 영향

• 영문명: Effect of Phenazine Dioxide Derivatives on the Hepatic Xanthine Oxidase Activity
• 발행기관: 대한약학회
• 저자명: 강일영(Il Young Kang) 김상렬(Sang Yul Kim) 김호식(Ho Shik Kim) 허근(Keun Huh)
• 간행물 정보: 『약학회지』제34권 제2호 (1990년), 112~116쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.04.28

영문 초록

8-Acyl-2-hydroxyphenzaine-5,10-dioxides and 8-acyl-2-aminophenazine-5,10-dioxides bearing n-butanoyl, n-hexanoyl and n-octanoyl groups were synthesized. It was attempted to observe the effect of phenazine dioxide derivatives on the hepatic xanthine oxidase activity in this study. As the activity of xanthine oxidase, the key enzyme in the generation of superoxide anion radical (O2), was measured in the presence of phenazine dioxide derivatives, the action of 8-acyl-2-hydroxyphenazine-5,10-dioxide derivatives inhibited with increase of numbers of carbon atom bearing 8-acyl group. Moreover, when plotted on double reciprocal form, the Vmax value decrease as increase of numbers of carbon atom bearing acyl groups without affecting the Km value. However, the hepatic xanthine oxidase activity was not changed by 8-acyl-2-aminophenazine-5,10-dioxide derivatives.

키워드

Phenazine dioxide derivatives hepatic xanthine superoxide anion radical oxidase.