충치균에 대한 생리활성 생약성분의 분리 및 약효평가(1) 튜립나무잎의 항균성 성분과 안전성에 대하여

• 영문명: The Isolation and Evaluation of Bioactive Components from Crude Drugs against a Cariogenic Bacterium, Streptococcus mutans OMZ 176 (1) On the Antibacterial Component of the Leaves of Liriodendron tulipifera and Its Safety
• 발행기관: 대한약학회
• 저자명: 배기환(Ki Whan Bae) 김봉희(Bong Hee Kim) 명평근(Pyung Keun Myung) 변재화(Jae Hwa Byun)
• 간행물 정보: 『약학회지』제34권 제2호 (1990년), 106~111쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.04.28

영문 초록

The isolation and identification of an antibacterial component, from the leaves of Liriodendron tulipifera. K. Kotch against a cariogenic bacterium Streptococcus mutans OMZ 176, were carried out for developing of anticariogenic agents. The bioactive component was elucidated as beta-liriodenolide, which was isolated newly from the leaves of L. tulipifera. The minimal inhibitory concentration (MIC) of beta-liriodenolide was 100mcg/ml and the antibacterial activity was stronger than that of berberine. beta-Liriodenolide inhibited beta-lactamase activity, 50, 100 and 200mcM beta-liriodenolide did beta-lactamase activity as 0.7, 3.5 and 19.7%, respectively. The toxicity of beta-liriodenolide was not found with the method of photohemolysis.