소염진통제의 개발 I. Isoxazole 유도체

• 영문명: Development of Antiinflammatory Agents I. Isoxazole Derivatives
• 발행기관: 대한약학회
• 저자명: 박노상(No Sang Park) 김현숙(Hyun Sook Kim) 민창희(Chang Hee Min) 최중권(Joong Kwon Choi)
• 간행물 정보: 『약학회지』제34권 제2호 (1990년), 80~87쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.04.28

영문 초록

3-Substituted 5-aminoisoxazole-4-carboxylates were prepared by the reaction of corresponding bormoaldoximes with cyanoacetate. The 3-trifluoromethylisoxazole derivatives were acylated to amides with various aminopyridine derivatives to afford diamides. The ester group was hydrolyzed and decarboxylated easily to give 3-trifluoromethyl-5-aminoisoxazole. The aminoisoxazole was also converted to amides. 5-Amino-3-trifluoromethylisoxazole-5-one-4-carboxylate was prepared by the reaction of trifluoroacetoaldoximoyl bromide and malonate. 5-Amino-3-methylisoxazole-5-one-4-acetate was prepared by the reaction of hydroxylamine and acetylmalonate. The synthesized compounds were tested for antiinflammatory activities.