Cypermethrin과 Piperonyl butoxide가 rat의 독성반응에 미치는 영향

• 영문명: Effect of Cypermethrin and Piperonyl Butoxide on Toxic Response in Rats
• 발행기관: 대한약학회
• 저자명: 정규혁(Kyu Hyuok Chung) 홍사욱(Sa Uk Hong)
• 간행물 정보: 『약학회지』제34권 제2호 (1990년), 69~79쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.04.28

영문 초록

The aim of this experiment is to observe the toxicity of cypermethrin[S,R-alpha-cyano-3-phenoxybenzyl-(1R, ls, cis, trans)-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropane carboxlate],and to investigate the synergistic effect of piperonyl butoxide on the cypermethrin toxicity. In cypermethrin (CYP) treated group, the biochemical parameters such as ALT, LDH, glucose in serum were remarkably, elevated. The content of cytochrome P-450 and activity of NADPH-cytochrome c reductase in renal microsomal fraction were increased but those in hepatic microsomal fraction were not significantly increased. The activity of aniline hydroxylase and ATPase in liver were decreased. In the case of CYP plus piperonyl butoxide (PB) treated group, AST, ALT, LDH and glucose were more increased. Cytochrome P-450 and NADPH-cytochrome c reductase in liver and kidney were supressed and aniline hydroxylase and ATPase in liver were more decreased. Especially, in the case of CYP plus PB 100mg/kg treated group, hepatic TBA value was increased but activity of glucose-6-phosphatase was remarkably, depressed

키워드

cis-Cypermethrin piperonyl butoxide biochemical parameters cytochrome p-450 NADPHcytochrome C reductase aniline hydroxylase ATPase TBA value glucose-6-phosphatase