개의 신장기능에 미치는 Captopril의 영향

• 영문명: Effect of Captopril on Renal Function in Dog
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 이민재(Min Jae Lee)
• 간행물 정보: 『약학회지』제34권 제2호 (1990년), 88~101쪽, 전체 14쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.04.28

영문 초록

Captopril, angiotensin converting enzyme (ACE) inhibitor, when given intravenously in dog, elicited the diuretic action along with the increases of glomerular filtration rates (GFR), renal plasma flow (RPF) and osmolar clearances(Cosm) with no changes of free water clearances (CH2O), and then captopril produced the enlargement of excretion rates of electrolytes in urine and the reduction of reabsorption rates of electrolytes in renal tubles. Captopril, when given into a renal artery, exhibited no changes of renal function in the experimental kidney, whereas diuretic action with the same mechanism as shown in intravenous captopril in control kidney. Captopril, when injected into a carotid kidney, showed increases in rates of urine flow in a small doses which did not affect on renal action when it was administered intravenously. Diuretic action induced by captopril was not influenced by renal artery denervation, propranolol and angiotensin II inhibiters. Above results suggest that captopril produced diuretic action along with renal hemodynamic changes by slight contraction of vas efferense and reduction of reabsorption rate of electrolytes in renal tubules, especially distal tubules, that may be mediated by endogenous substances.

키워드

Captopril glomerular filtration rate rcmal plasma flow renal artery carotid artery excretion and reabsorption rates of Na and K diuretic action, dog.