푸로세미드와 안지오텐신 차단제와 상호작용

• 영문명: Interaction of Furosemide and Angiotensin Inhibitor
• 발행기관: 대한약학회
• 저자명: 최준식(Jun Shik Choi) 이진환(Jin Hwan Lee) 범진필(Jin Pil Burm)
• 간행물 정보: 『약학회지』제33권 제6호 (1989년), 345~349쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.12.28

영문 초록

This paper was attempted to investigate effect of angiotensin inhibitor (loading dose 25, 50, 100mcg/kg and maintenance dose 12.5, 25, 50mcg/kg/hr) on the pharmacokinetics of furosemide (5mg/kg i.v) in rabbit. The plasma concentrations of furosemide increased by angiotensin inhibitor and the relative bioavailability of furosemide increased from 118.1% to 193.2% by the inhibitor. The protein binding of furosemide decreased by angiotensin inhibitor in bovine serum albumin (2.17 X 10-4M) by equilibrium dialysis method. Consequently, dosage regimen of furosemide might be adjusted carefully when furosemide is administered with angiotensin inhibitor.

키워드

Furosemide angiotensin inhibitor pharmacokinetics plasma concentration urinary excretion bioavailability protein binding bovine serum albumin equilibrium dialysis method.