Sodium Tripolyphosphate-Chitosan의 Polyelectrolyte Complex Coating이 Sulfanilamide 과립의 용출에 미치는 영향

• 영문명: The Effect on the Dissolution Rate of Sulfanilamide Granules Coatedwith a Polyelectrolyte Complex of Sodium Tripolyphosphate-Chitosan
• 발행기관: 대한약학회
• 저자명: 구영순(Young Soon Ku) 김자영(Ja Young Kim) 김길수(Kil Soo Kim)
• 간행물 정보: 『약학회지』제33권 제6호 (1989년), 324~332쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.12.28

영문 초록

Drug release from sulfanilamide granules coated with a polyelectrolyte complex of sodium tripolyphosphate and chitosan was studied. The coating film thickness increased with increasing concentration of chitosan in the coating solution and the drug release rates of the coated granules were significantly reduced comparing with those of the uncoated granules. T50% of the uncoated granules was 6 minutes, but those of the granules coated with chitosan-sodium tripolyphosphate from 0.5, 0.7, and 0.9% (w/v) chitosan-HCl solution were 27, 135, and 180 minutes, respectively in distilled water. In dissolution medium at pH 6.8, T50% of the uncoated granules was 4 minutes, but those of the granules coated with chitosan-sodium tripolyphosphate from 0.5, 0.7, and 0.9(w/v)% chitosan-HCl solution, were 32, 135, and 160 minutes, respectively.

키워드

Sulfanilamide Chitosan-sodium tripolyphosphate complex coating film thickness