Piperine이 적출 백서 정관내의 교감신경계에 미치는 영향

• 영문명: Effect of Piperine on Peripheral Sympathetic Nervous System in Isolated Vas deferens of Rat
• 발행기관: 대한약학회
• 저자명: 은재순(Jae Soon Eun)
• 간행물 정보: 『약학회지』제32권 제1호 (1988년), 55~61쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.02.28

영문 초록

To elucidate one of the effect of piperine on the peripheral sympathetic nervous system, influence of piperine upon the contractile action of norepinephrine, methoxamine and tyramine as well as uptake and release of [3H]-norepinephrine has been investigated in naive and chronic piperine-treated vas deferens of rats. pA2 value for alpha1-adrenoceptor of phentolamine was significantly increased. Chronic piperine-treated group was markedly shown increased efflux of [3H]-norepinephrine and muscular tension, but was not affected the neuronal up-take and release of [3H]-norepinephrine. It can be concluded that potentiation of the effect of norepinephrine by acute and chronic piperine treated group may be due to the change of affinity of alpha1-adrenoceptor, and partly due to possible modification of storage mechanism.