오가피 성분의 항돌연변이원성에 관한 연구

• 영문명: Studies on the Antimutagenic Effect of Acanthopanax sessiliflorumComponents
• 발행기관: 대한약학회
• 저자명: 정규찬(Kyu Charn Chung) 백석환(Suk Hwan Baek) 남경수(Kyung Soo Nam)
• 간행물 정보: 『약학회지』제32권 제1호 (1988년), 14~19쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.02.28

영문 초록

Effects of acanthopanax cortex extracts on glutathion S-transferase (GST), glutathion peroxidase (GSH-px) and superoxide dismutase (SOD) activities related to 7,12-dimethyl-benz(a)anthracene (DMBA) metabolism and on DMBA-induced mutagenicity were investigated in this study. From the comparative study of three extracts, it was found that butanol extract was more potent than other extracts in increment of GST, GSH-px and SOD activities and in inhibitory effects of lipoperoxide formation of liver. Also ether and butanol extracts inhibited DMBA-induced mutagenicity, showing 33% to 36% of inhibition at maximum, when ether and butanol extracts were administered to rats intraperitoneally.