뇌내 Norepinephrine함량변화와 Clonazepam의 항경련효과에 미치는 6-Hydroxydopamine의 영향

• 영문명: The Effect of 6-Hydroxydopamine on the Anticonvulsant Activity of Clonazepam and Norepinephrine in Brain
• 발행기관: 대한약학회
• 저자명: 윤재순(Jae Soon Yun) 김영주(Young Joo Kim)
• 간행물 정보: 『약학회지』제32권 제1호 (1988년), 40~49쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.02.28

영문 초록

There is evidence that brain norepinephrine may play a role in experimentally induced seizures in animals. Thus the present experiments were undertaken in an attempt to explore the role of brain norepinephrine in anticonvulsant activity of clonazepam. 6-Hydroxydopamine was given to newborn rats and PTZ-induced seizures were tested 70-90 days after birth and the rats were killed for determination of brain norepinephrine 8 days after the seizure test. Depletion of norepinephrine in the rat brain significantly potentiated the PTZ-induced convulsions and antagonized the effect of clonazepam on clonic seizures, tonic seizures and the number of seizures, but the latency to the seizure and the mortality has not been altered. However the 6-hydroxydopamine-induced antagonism of anticonvulsant action was surmountable by increasing the dose of clonazepam. These results show that brain norepinephrine may play an important role in seizure susceptibility as well as in the anticonvulsant activity of clonazepam in rats.