만성적인 에탄올 섭취 시 수종 천연 추출물 투여가 흰쥐의 혈청과 간의 지질 함량에 미치는 영향

• 영문명: Effects of Herbal Extracts on Serum and Liver Lipid Levels in Chronic Ethanol Administered Rats
• 발행기관: 대한약학회
• 저자명: 김목경(Mok Kyung Kim) 이용혁(Young Hyuk Lee) 현선희(Sun Hee Hyun) 정세영(Se Young Chung)
• 간행물 정보: 『약학회지』제49권 제6호 (2005년), 477~483쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.12.31

영문 초록

This study had been done for the investigation of the effect of Vitis vinifera extract (VV), Schisandra chinensis extract (SC), Taraxacum officinale extract (TO), Gardenia jasminoides extract (GJ), Angelica acutiloba extract (AA) and Paeonia japonica extract (PJ) on fatty liver and hepatotoxicity which was induced by Lieber-DeCarli ethanol liquid diet. Male Sprague-Dawley rats were randomly divided into eight groups: ethanol diet(ED), normal diet(ND), ED+VV(100㎎/㎏), ED+SC, ED+TO, ED+GJ, ED+AA, and ED+PJ (300㎎/㎏/day). Rats fed liquid diets for 6 weeks showed remarkable increase in serum and hepatic lipids indicating the onset of alcoholic fatty liver. The increasing levels of GPT, ALP activities in serum were observed in the groups fed with alcohol-containing diets compared to those of the ND group. The VV, SC, TO, GJ, AA and PJ groups were decreased the levels of triglyceride, free fatty acid and total cholesterol in serum and liver and GPT, ALP activities in serum. Therefore, they can be utilized as a health functional food or new drug candidate for fatty liver and hepatotoxicity which was induced by chronic alcohol consumption.

키워드

fatty liver hepatotoxicity Vitis vinifera Schisandra chinensis Taraxacum officinale Gardenia jasminoides Angelica acutiloba and Paeonia japonica