옻나무 플라보노이드가 수컷 백서의 성행동에 미치는 영향

• 영문명: The Effect of Flavonoid Fraction Extracted from Rhus verniciflua Stokes on Sexual Behavior in SD Male Rats
• 발행기관: 대한약학회
• 저자명: 나천수(Chun Soo Na) 최범락(Bum Rak Choi) 추동환(Dong Wan Choo) 최원일(Won Il Choi) 김진범(Jin Bum Kim) 김현정(Hyun Jung Kim) 정연준(Yun Jun Chung) 박영인(Young In Park) 동미숙(Mi Sook Dong)
• 간행물 정보: 『약학회지』제49권 제6호 (2005년), 471~476쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.12.31

영문 초록

Rhus verniciflua Stokes (RVS) has been used as a food supplement and a traditional herbal medicine for a men's sexual enhancement. In this study, we prepared a flavonoid fraction (RWE) from a hot water extract of RVS and its influence on sexual behavior was studied in male rats which were orally administered varying doses of RWE for 2 weeks. All doeses of RWE stimulated sexual behavior in male rats such as reducing mounting latency and enhancing mount frequencies. However, intermission numbers were not changed and none of group can observe the ejaculation during behavioral testing time 5 min. Testosterone levels were increased about 0~53% and 92~164% by the treatment of RWE for 1 and 2 weeks, respectively. However, estrogen levels in male rats teded to decrease in a dose dependent manner of RWE. At the dose of RWE 200㎎/㎏, estrogen level was reduced to 77.5% and 70.3% of control after 1 and 2 weeks treatment. These findings suggest that the Rhus flavonoid fraction can stimulate the androgen-dependent male sexual behavior and it can applied to the material of functional food for enhancing the sexual function.

키워드

Rhus verniciflua Stokes flavonoids male rat sexual behavior