매생이 추출물의 멜라닌생성 억제효과

• 영문명: Inhibitory Effect on the Melanogenesis of Capsosiphon fulvescens
• 발행기관: 대한약학회
• 저자명: 문연자(Yeun Ja) 유현주(Hyun Ju Yoo) 이경은(Kyung Eun Lee) 김진희(Jin Hui Kim) 표형배(Hyeong Bae Pyo) 우원홍(Won Hong Woo)
• 간행물 정보: 『약학회지』제49권 제5호 (2005년), 375~379쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.10.31

영문 초록

The green marine algae, Capsosiphon fulvescens is one of the important economic seaweeds cultured in Korea. In this study, we investigated the effects of Capsosiphon fulvescens on melanogenesis using B16 cells. Our results showed that Capsosiphon fulvescens significantly inhibits melanin synthesis and it reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. Western Blot analysis using anti-tyrosinase antibody revealed that Capsosiphon fulvescens (10~40μg/ml) decreased tyrosinase protein levels. Cell proliferation was dose-dependently inhibited by 10, 20 and 40 μg/ml Capsosiphon fulvescens, without cytotoxicity and morphological change. These results suggest that the depigmenting effect of Capsosiphon fulvescens is correlated with the suppression of tyrosinase activity and protein level, which are key enzymes for melanogenesis.

키워드

melanin tyrosinase Capsosiphon fulvescens cytotoxicity