우유속 락토페린의 NMDA 수용체를 통한 진통효과

• 영문명: Effect of NMDA Receptor on Analgesic Effect of Bovine Milk-derived Lactoferrin (BLF)
• 발행기관: 대한약학회
• 저자명: 전용준(Yong Joon Jeon) 윤재석(Jae Suk Yun) 임화경(Hwa Kyung Lim) 박기숙(Ki Suk Park) 나한광(Han Kang Na) 김동섭(Dong Sup Kim) 김주일(Joo Il Kim) 윤여창(Yea Chang Yoon) 최기환(Ki Hwan Choi)
• 간행물 정보: 『약학회지』제49권 제5호 (2005년), 370~374쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.10.31

영문 초록

Lactoferrin is a multifunctional protein that is found in milk, neutrophils, and other biological fluids, and its receptors have also been identified in the central nervous system. Recently, it was reported that bovine milk-derived lactoferrin (BLF) produced analgesia via a μ-opioid receptor-mediated response in the spinal cord. However the precise mechanism of this analgesic effect is remains unclear. In Randall-Selitto paw pressure study, each single administration of morphine (10 mg/kg) and BLF (50, 100 and 200 mg/kg) induced analgesia, however, NMDA receptor antagonist MK-801 (0.1, 0.2 and 0.3 mg/kg), inhibited analgesia induced by BLF(100mg/kg). Intracerebroventricular infusion (I.C.V) of N-methyl-D-aspartic acid (NMDA) (0.3 μg/8.0 μl/hr/day), as a NMDA receptor agonist, reversed inhibition of MK-801 (0.3mg/kg) on analgesia induced by BLF (100mg/kg). These results suggest that BLF have analgesic effect, through NMDA receptor activation.

키워드

morphine lactoferrin MK-801 NMDA analgesia