구지뽕나무 잎의 항산화 성분

• 영문명: Anti-oxidant Compounds of Cudrania tricuspidata Leaves
• 발행기관: 대한약학회
• 저자명: 전인주(In Ju Chon) 이성환(Seong Wan Lee) 차자현(Ja Hyun Cha) 한정훈(Jeong Hoon Han) 황완균(Wan Kyunn Whang)
• 간행물 정보: 『약학회지』제49권 제5호 (2005년), 416~421쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.10.31

영문 초록

Cudrania tricuspidata Bereau (Moraceae) have been used for anti-inflammatory, anti-hepatotoxic, anti-hypertensive and anti-diabetic activities. In order to investigate the efficacy of antioxidant activity, the bio-activity guided fraction and isolation of Biologically active substance were performed. H2O, 30%, 60%, 100% MeOH and acetone fractions were examined on the antioxidant activity by DPPH method. It was shown that 30%, 60%, 100% MeOH fractions have significantly antioxidant activity. From 30% MeOH fraction, two dihydroflavonoid glycosides dihydroquercetin 7-O-β-D-glucopyranoside (I), dihydrokaempferol 7-O-β-D-glucopyranoside (V) were isolated and 60% MeOH fraction, six flavonoids including quercetin 3-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (Ⅱ), quercetin 3-O-β-D-glucopyranoside (Ⅲ), quercetin 7-O-β-D-glucopyranoside (Ⅳ), kaempferol 3-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (Ⅵ), kaempferol 3-O-β-D-glucopyranoside (Ⅶ), kaempferol 7-O-β-D-glucopyranoside (Ⅷ) were isolated. To investigate the antioxidant activities of each compounds, we measured radical scavening activity with DPPH method and anti-lipid peroxidative efficacy on low density lipoprotein (LDL) with TBARS assay. Four compounds of quercetin glycosides (Ⅰ,Ⅱ,Ⅲ,Ⅳ) showed significant antioxidant activity.

키워드

Cudrania tricuspidata Bureau DPPH method TBARS assay quercetin glycoside kaempferol glycoside