Elevated Plus-maze를 이용한 Phenylpropanoid의 항불안 효과

• 영문명: Anxiolytic-like Effects of Phenylpropanoids Using the Elevated Plus-Maze in Mice
• 발행기관: 대한약학회
• 저자명: 윤병훈(Byung Hoon Yoon) 최지웅(Ji Woong Choi) 정지욱(Ji Wook Jung) 신진선(Jin Sun Shin) 현성예(Seong Ye Hyeon) 정재훈(Jae Hoon Cheong) 류종훈(Jong Hoon Ryu) 고광호(Kwang Ho Ko)
• 간행물 정보: 『약학회지』제49권 제5호 (2005년), 437~442쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.10.31

영문 초록

The purpose of this study was to characterize the putative anxiolytic-like effects of phenylpropanoids using the elevated plus maze (EPM) test in mice. Cinnamic acid, p-coumaric acid, caffeic acid and ferulic acid were orally administered to male ICR mice, 1 h before behavioral evaluation in an EPM, respectively. Control mice were treated with an equal volume of vehicle, and positive control mice diazepam(1 mg/kg). A single treatment with phenylpropanoids (at 8 mg/kg) significantly increased time-spent and arm entries into the open arms of the EPM., and decreased time-spent and arm entries into the closed arms of the EPM versus control (P〈 0.05). However, no changes in the locomotor activity and myorelaxant effect were seen in any group versus the saline control. These results suggest that phenylpropanoids may be an effective anxiolytic agent.

키워드

anxiety cinnamic acid P-coumaric acid caffeic acid ferulic acid elevated plus-maze