녹차카테킨과 에피갈로카테킨갈레이트의 산화적 스트레스에 대한 억제효과

• 영문명: Protective Effects of Green Tea Catechins and (-)-Epigallocatechin gallate on Reactive Oxygen Species-Induced Oxidative Stress
• 발행기관: 대한약학회
• 저자명: 윤여표(Yeo Pyo Yun) 박종범(Jong Bum Park) 허문영(Moon Young Heo)
• 간행물 정보: 『약학회지』제45권 제1호 (2001년), 101~107쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.02.28

영문 초록

Green tea catechins (GTC) and its major component, (-)-epigallocatechin gallate (EGCG) were studied for their protective effect against reactive oxygen species (ROS)-induced oxidative stress. GTC and EGCG showed the strong antioxidative effects on the lipid peroxidation of ethyl linolate with Fenton's reagent and free radical scavenging effect to DPPH radical generation. They also protected H2O2-or KO2-induced cytotoxicity in CHL cells or mouse splenocytes. These results indicate that GTC and EGCG are acpable of protecting the lipid peroxidation, free radical generation and cytotoxicity induced by ROS. The mechanism of inhibition in ROS-induced cytotoxicity may be due to their antioxidative and free radial scavenging properties. Therefore, GTC and EGCG may be useful chemopreventive agents by protecting the free radical generation which are involved in cancer and aging.

키워드

Green tea catechins EGCG reactive oxygen species antioxidative effect chemoprevention