이온교환체로서 금속-페난드롤린-메페남산 3원 착물을 이용한 메페남산의 정량

• 영문명: Determination of Mefenamic acid with ISEs using Ternary complex of Metal-phenanthroline-mefenamate as Ion-exchanger
• 발행기관: 대한약학회
• 저자명: 허문회(Moon Hye Hur) 김대병(Dae Byung Kim) 남수자(Soo Ja Nam) 문현숙(Hyun Sook Moon) 이미나(Mi Na Lee) 정문모(Moon Mo Jung) 안문규(Moon Kyu Ahn)
• 간행물 정보: 『약학회지』제45권 제1호 (2001년), 29~33쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.02.28

영문 초록

A method for the determination of anionic drug, mefenamate with ion-selective electrode using Fe(II)-1,10-phenanthroline chelate as a counter ion was developed. Benzyl nitrophenyl ether (BNPE) plasticized membrane was more selective and sensitive than the other tested membranes. This membrane electrode exhibits a linear response for 10-2 M~5 ×10-5 M of mefenamic acid with a slope of - 61.4mV/dec. in borate buffer sloutions (Ph 9.0). Potentiometric selectivity measurements revealed negligible interferences from various organic and ionorganic anions. Direct potentiometry and potentiometric titration method of mefenamic acid in capsule preparations are presented and compared.

키워드

ISEs Mefenamate direct potentiometry potentiometric titration Fe(II)-l 10-phenanthroline