Cinmetacin 유도체의 합성과 진통항염활성

• 영문명: Synthesis and Analgesic-antiinflammatory Activity of Cinmetacin Derivatives
• 발행기관: 대한약학회
• 저자명: 임채욱(Chaeuk Im) 이종민(Jong M in Lee) 유재학(Jai Hag Rhu) 이현수(Hyun Soo Lee) 임철부(Chul Bu Y im)
• 간행물 정보: 『약학회지』제45권 제1호 (2001년), 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.02.28

영문 초록

Nine cinmetain derivatives as potential nonsteroidal analgesic and antiinflammatory compounds were prepared and their analgesic-antiinflammatory activity was compared with conmetacin. Salicylic acid and phenols were reacted with dicyclohexyl carbodiimide (DCC) to give phenyl salicylates (1-4). Cinmetacin was treated with DCC and phenol derivatives to yield cinmetacin esters (5-13). Compounds(5, 7, 8, 10, 12, and 13) showed stronger analgesic activity than cinmetacin, but only compound (5) showed comparable antiinflammatory to cinmetacin.

키워드

Cinmetacin esters analgesic agent antiinflammatory agent