효모에서 발현된 유전자 재조합 탈메치오닌 인간 성장호르몬의 일반 약리작용

• 영문명: General Pharmacology of Recombinant Human Growth Hormone without N-Terminal Methionine Expressed in Saccharomyces cerevisiae
• 발행기관: 대한약학회
• 저자명: 이은방(Eun Bang Lee) 신국현(Kuk Hyun Shin) 김운자(Oon Ja Kim) 윤기영(Ki Young Yoon) 천선아(Seon Ah Cheon) 채윤정(Yun Jung Chae)
• 간행물 정보: 『약학회지』제36권 제1호 (1992년), 17~25쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.02.28

영문 초록

The general and some other pharmacological actions of growth hormone without N-terminal methionine(rhGH) were investigated in animals. The hormone had no influenced on the central nervous system and on body temperature at a high oral dose of 40IU/kg in animals. It had neither analgesic nor antiepileptic actions at the High doses. In the isolated ileum and trachea of guinea-pig and isolated stomach fundus and uterus of rat, it showed neither contractive nor relaxing effets at a concentration of 1 X 10-3IU/ml in bath, and no inhibitory action at a dose of 1 X 10-3IU/ml against the contractions produced by histamine (5 X 10-5g/ml), serotonin(1 X 10-5g/ml, acetylcholine(1 X 10-5g/ml) and oxytocin(5 X 10-3IU/ml). Furthermore, the intravenous infection of 20IU/kg rhGH had no influences on the normal blood pressure and respiration in rabbits. These negative results in pharmacological profile are thought that the hormone may not elicit serious side effects On the other hand, the rhGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomiglucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration of 80IU/kg, and showed a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.