2-(p-메틸알릴아미노페닐)프로판산의 합성

• 영문명: Facile Synthesis of 2-(p-Methylallylaminophenyl)propionic Acid(Alminoprofen)
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi) 윤호상(Ho Sang Yun) 강병원(Byung Won Kang) 마정주(Jung Joo Ma) 손병화(Byeng Wha Son)
• 간행물 정보: 『약학회지』제36권 제1호 (1992년), 12~16쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.02.28

영문 초록

A new method for the synthesis of alminoprofen, which is a non-steroidal antiinflammatory agent, was described. Ethyl 2-phenyl-propionate(4) was prepared by Friedel-Crafts reaction of benzene with ethyl alpha-chloro-alpha(methylthio)acetate(1), followed by methylation and desulfurization of the resultant ethyl 2-(methylthio)phenylacetate(2). Ethyl 2-(p-aminophenyl)propionate(6) was obtained by nitration of (4) and successive reduction of ethyl 2-(p-nitrophenyl)propionate(5). Alminoprofen was synthesized by reaction of (6) with methallyl chloride, followed by hydrolysis of the resultant ethyl 2-(p-methylallylaminophenyl)propionate(7).