Imidazo-thiazole 쯔비터 이온 유도체의 합성과 반응성

• 영문명: Synthesis and Reactivity of Zwitterionic Bicyclic Imidazo-thiazole Derivatives
• 발행기관: 대한약학회
• 저자명: 박상우(Sang Woo Park) 김동찬(Dong Chan Kim)
• 간행물 정보: 『약학회지』제29권 제1호 (1985년), 39~42쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1985.02.28

영문 초록

Betaines of bicyclic imidazo-thiazoles were synthesized by the reaction of electrophiles such as methyl isocyanate, methyl isothiocyanate, allyl isothiocyanate and ketene with 3-methyl and 3-phenyl-5,6-dihydroimidazo[2,1-b]thiazole. In this reaction, the methyl group which was substituted at 3-position increased the yields of the products in comparison with those from phenyl group substituted substrates. Also, the betaines reacted with methyl iodide to give imidazo-thiazolium salts which were unstable at high temperature and converted the quaternary ammonium salts of original biheterocycles.