Cinnarizine을 Propranolol이나 Metoprolol과 병용할 때의 행동약리학적 연구

• 영문명: Pharmacological Studies on the Behavioral Effects of Cinnarizine Coadministered with Propranolol or Metoprolol
• 발행기관: 대한약학회
• 저자명: 허인회(In Hoi Huh) 안형수(Hyung Soo Ann)
• 간행물 정보: 『약학회지』제29권 제1호 (1985년), 11~17쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1985.02.28

영문 초록

The behavioral effects of propranolol (60mg/kg) and metoprolol (100mg/kg) each alone and coadministered orally with cinnarizine (100mg/kg) were investigated and compared with each of beta-blockers alone treated group in rodents. Propranolol showed depressive effects through locomotor activity, conditioned avoidance response, rota-rod test, traction test, and analgesic effect in mice. When combined with cinnarizine and propranolol, the behavioral depressive effect of propranolol was reduced comparing with propranolol alone treated group. However, metoprolol alone or combined with cinnarizine didn''t showed any behavioral depressive effect so much as propranolol.